6TRY
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with MF13 inhibitor compound
Summary for 6TRY
Entry DOI | 10.2210/pdb6try/pdb |
Descriptor | Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 8-(4-chlorophenyl)-2-phenyl-imidazo[1,2-a]pyridine, ... (5 entities in total) |
Functional Keywords | dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 114383.07 |
Authors | Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2019-12-19, release date: 2021-01-13, Last modification date: 2024-01-24) |
Primary citation | Quattrini, L.,Gelardi, E.L.M.,Petrarolo, G.,Colombo, G.,Ferraris, D.M.,Picarazzi, F.,Rizzi, M.,Garavaglia, S.,La Motta, C. Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2- a ]pyridines against the 1A Family. Acs Med.Chem.Lett., 11:963-970, 2020 Cited by PubMed: 32435412DOI: 10.1021/acsmedchemlett.9b00686 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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