6TQG

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

Summary for 6TQG

Entry DOI	10.2210/pdb6tqg/pdb
Descriptor	Glucose-1-phosphate thymidylyltransferase, ~{N}-[1-[(4-bromophenyl)methyl]-6-[3-(methylamino)propylamino]-2,4-bis(oxidanylidene)pyrimidin-5-yl]-~{N}-methyl-benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	rmla, allostery, thymidylyltransferase, inhibitor, transferase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	4
Total formula weight	137866.82
Authors	Alphey, M.S.,Xiao, G.,Westwood, J.N. (deposition date: 2019-12-16, release date: 2020-08-19, Last modification date: 2024-01-24)
Primary citation	Xiao, G.,Alphey, M.S.,Tran, F.,Pirrie, L.,Milbeo, P.,Zhou, Y.,Bickel, J.K.,Kempf, O.,Kempf, K.,Naismith, J.H.,Westwood, N.J. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg.Med.Chem., 50:116477-116477, 2021 Cited by PubMed: 34757294 DOI: 10.1016/j.bmc.2021.116477 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation