6TQG

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

6TQG の概要

• エントリーDOI: 10.2210/pdb6tqg/pdb
• 分子名称: Glucose-1-phosphate thymidylyltransferase, ~{N}-[1-[(4-bromophenyl)methyl]-6-[3-(methylamino)propylamino]-2,4-bis(oxidanylidene)pyrimidin-5-yl]-~{N}-methyl-benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: rmla, allostery, thymidylyltransferase, inhibitor, transferase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 137866.82

構造登録者

Alphey, M.S.,Xiao, G.,Westwood, J.N. (登録日: 2019-12-16, 公開日: 2020-08-19, 最終更新日: 2024-01-24)

• 主引用文献: Xiao, G.,Alphey, M.S.,Tran, F.,Pirrie, L.,Milbeo, P.,Zhou, Y.,Bickel, J.K.,Kempf, O.,Kempf, K.,Naismith, J.H.,Westwood, N.J.; Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design.; Bioorg.Med.Chem., 50:116477-116477, 2021; PubMed: 34757294; DOI: 10.1016/j.bmc.2021.116477

実験手法

X-RAY DIFFRACTION (2.45 Å)