6TPR

PqsR (MvfR) bound to inhibitory compound 40

6TPR の概要

• エントリーDOI: 10.2210/pdb6tpr/pdb
• 分子名称: Transcriptional regulator MvfR, 2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-~{N}-(4-pyridin-2-yloxyphenyl)ethanamide (3 entities in total)
• 機能のキーワード: pseudomonas aeruginosa, quorum sensing, dna binding protein
• 由来する生物種: Pseudomonas aeruginosa UCBPP-PA14
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27191.69

構造登録者

Richardson, W.K.,Emsley, J. (登録日: 2019-12-14, 公開日: 2020-05-13, 最終更新日: 2024-01-24)

• 主引用文献: Soukarieh, F.,Liu, R.,Romero, M.,Roberston, S.N.,Richardson, W.,Lucanto, S.,Oton, E.V.,Qudus, N.R.,Mashabi, A.,Grossman, S.,Ali, S.,Sou, T.,Kukavica-Ibrulj, I.,Levesque, R.C.,Bergstrom, C.A.S.,Halliday, N.,Mistry, S.N.,Emsley, J.,Heeb, S.,Williams, P.,Camara, M.,Stocks, M.J.; Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm GrownPseudomonas aeruginosa.; Front Chem, 8:204-204, 2020; PubMed: 32432073; DOI: 10.3389/fchem.2020.00204

実験手法

X-RAY DIFFRACTION (3.2 Å)