6TPJ
Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution
Summary for 6TPJ
Entry DOI | 10.2210/pdb6tpj/pdb |
Descriptor | Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2, OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, ... (6 entities in total) |
Functional Keywords | 7tm, gpcr, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 140024.38 |
Authors | Rappas, M.,Ali, A.,Bennett, K.A.,Brown, J.D.,Bucknell, S.J.,Congreve, M.,Cooke, R.M.,Cseke, G.,de Graaf, C.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Mason, J.S.,Mould, R.,Patel, J.C.,Tehan, B.G.,Weir, M.,Christopher, J.A. (deposition date: 2019-12-13, release date: 2020-01-01, Last modification date: 2024-01-24) |
Primary citation | Rappas, M.,Ali, A.A.E.,Bennett, K.A.,Brown, J.D.,Bucknell, S.J.,Congreve, M.,Cooke, R.M.,Cseke, G.,de Graaf, C.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Mason, J.S.,Mould, R.,Patel, J.C.,Tehan, B.G.,Weir, M.,Christopher, J.A. Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis. J.Med.Chem., 63:1528-1543, 2020 Cited by PubMed: 31860301DOI: 10.1021/acs.jmedchem.9b01787 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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