6TO2

Crystal structure of CYP154C5 from Nocardia farcinica in complex with 5alpha-Androstan-3-one

6TO2 の概要

• エントリーDOI: 10.2210/pdb6to2/pdb
• 分子名称: Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (5~{S},8~{S},9~{S},10~{S},13~{S},14~{S})-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one, ... (5 entities in total)
• 機能のキーワード: cytochrome p450, steroid hydroxylating monooxygenase, steroid binding, oxidoreductase-substrate complex, oxidoreductase
• 由来する生物種: Nocardia farcinica IFM 10152
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92291.98

構造登録者

Rodriguez, A.,Kluenemann, T.,Blankenfeldt, W.,Schallmey, A. (登録日: 2019-12-11, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Bracco, P.,Wijma, H.J.,Nicolai, B.,Buitrago, J.A.R.,Klunemann, T.,Vila, A.,Schrepfer, P.,Blankenfeldt, W.,Janssen, D.B.,Schallmey, A.; CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering*.; Chembiochem, 22:1099-1110, 2021; PubMed: 33145893; DOI: 10.1002/cbic.202000735

実験手法

X-RAY DIFFRACTION (2 Å)