6TMC

VIM-2_1dh-Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases

6TMC の概要

• エントリーDOI: 10.2210/pdb6tmc/pdb
• 分子名称: Beta-lactamase class B VIM-2, 4-[2-(phenylsulfonyl)ethyl]-5-(propan-2-yloxymethyl)-1~{H}-1,2,3-triazole, ZINC ION, ... (6 entities in total)
• 機能のキーワード: metallo-beta-lactamase inhibitor, nh-triazole, inhibition properties, crystal structure., antibiotic
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28936.95

構造登録者

Leiros, H.-K.S.,Christopeit, T. (登録日: 2019-12-04, 公開日: 2020-07-22, 最終更新日: 2024-01-24)

• 主引用文献: Muhammad, Z.,Skagseth, S.,Boomgaren, M.,Akhter, S.,Frohlich, C.,Ismael, A.,Christopeit, T.,Bayer, A.,Leiros, H.S.; Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases.; Bioorg.Med.Chem., 28:115598-115598, 2020; PubMed: 32631568; DOI: 10.1016/j.bmc.2020.115598

実験手法

X-RAY DIFFRACTION (1.4 Å)