6TM9

VIM-2_1cc-. Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases

6TM9 の概要

• エントリーDOI: 10.2210/pdb6tm9/pdb
• 分子名称: Beta-lactamase class B VIM-2, 2,5-bis(chloranyl)-~{N}-[[5-[(cyclohexylamino)methyl]-2~{H}-1,2,3-triazol-4-yl]methyl]benzenesulfonamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: metallo-beta-lactamase inhibitor, nh-triazole, inhibition properties, crystal structure., antibiotic
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28919.00

構造登録者

Leiros, H.-K.S. (登録日: 2019-12-03, 公開日: 2020-07-22, 最終更新日: 2024-01-24)

• 主引用文献: Muhammad, Z.,Skagseth, S.,Boomgaren, M.,Akhter, S.,Frohlich, C.,Ismael, A.,Christopeit, T.,Bayer, A.,Leiros, H.S.; Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases.; Bioorg.Med.Chem., 28:115598-115598, 2020; PubMed: 32631568; DOI: 10.1016/j.bmc.2020.115598

実験手法

X-RAY DIFFRACTION (1.07 Å)