6TLD

Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 2

6TLD の概要

• エントリーDOI: 10.2210/pdb6tld/pdb
• 分子名称: Histone deacetylase, ZINC ION, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase
• 由来する生物種: Schistosoma mansoni
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206030.09

構造登録者

Shaik, T.B.,Romier, C. (登録日: 2019-12-02, 公開日: 2019-12-18, 最終更新日: 2024-01-24)

• 主引用文献: Kalinin, D.V.,Jana, S.K.,Pfafenrot, M.,Chakrabarti, A.,Melesina, J.,Shaik, T.B.,Lancelot, J.,Pierce, R.J.,Sippl, W.,Romier, C.,Jung, M.,Holl, R.; Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.; Chemmedchem, 15:571-584, 2020; PubMed: 31816172; DOI: 10.1002/cmdc.201900583

実験手法

X-RAY DIFFRACTION (1.61 Å)