6TL9

CRYSTAL STRUCTURE OF LECTIN-LIKE OX-LDL RECEPTOR 1 IN COMPLEX WITH BI-0115

6TL9 の概要

• エントリーDOI: 10.2210/pdb6tl9/pdb
• 分子名称: Oxidized low-density lipoprotein receptor 1, GLYCEROL, 9-chloranyl-5-propyl-11~{H}-pyrido[2,3-b][1,4]benzodiazepin-6-one, ... (4 entities in total)
• 機能のキーワード: lox-1, olr1, ctld, c-type lectin like domain, scavenger receptor, oxldl binding, ppi stabilization, inhibitor, lipid binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 124278.68

構造登録者

Nar, H.,Fiegen, D.,Schnapp, G. (登録日: 2019-12-02, 公開日: 2020-07-22, 最終更新日: 2024-10-16)

• 主引用文献: Nar, H.,Fiegen, D.,Schnapp, G.; A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state; Commun Chem, 2020; DOI: 10.1038/s42004-020-0321-2

実験手法

X-RAY DIFFRACTION (2.734 Å)