6TKF

ChiLob 7/4 H2 HC-C225S KappaLC-C214S F(ab')2

This is a non-PDB format compatible entry.

Summary for 6TKF

• Entry DOI: 10.2210/pdb6tkf/pdb
• Descriptor: ChiLob 7/4 H2 Heavy chain C225S, ChiLob 7/4 H2 Kappa light chain C214S (3 entities in total)
• Functional Keywords: ----, immune system, antibody
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 48546.90

Authors

Orr, C.M.,Fisher, H.,Tews, I. (deposition date: 2019-11-28, release date: 2021-06-09, Last modification date: 2024-01-31)

• Primary citation: Orr, C.M.,Fisher, H.,Yu, X.,Chan, C.H.,Gao, Y.,Duriez, P.J.,Booth, S.G.,Elliott, I.,Inzhelevskaya, T.,Mockridge, I.,Penfold, C.A.,Wagner, A.,Glennie, M.J.,White, A.L.,Essex, J.W.,Pearson, A.R.,Cragg, M.S.,Tews, I.; Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.; Sci Immunol, 7:eabm3723-eabm3723, 2022; PubMed: 35857577; DOI: 10.1126/sciimmunol.abm3723

Experimental method

X-RAY DIFFRACTION (2.18 Å)