6TJ8

Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine diphosphate

Summary for 6TJ8

• Entry DOI: 10.2210/pdb6tj8/pdb
• Descriptor: Transketolase 1, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 2
• Total formula weight: 149254.04

Authors

Rabe von Pappenheim, F.,Tittmann, K. (deposition date: 2019-11-25, release date: 2020-07-08, Last modification date: 2024-01-24)

• Primary citation: Rabe von Pappenheim, F.,Aldeghi, M.,Shome, B.,Begley, T.,de Groot, B.L.,Tittmann, K.; Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine.; Nat.Chem.Biol., 16:1237-1245, 2020; PubMed: 32839604; DOI: 10.1038/s41589-020-0628-4

Experimental method

X-RAY DIFFRACTION (0.921 Å)