6TI7

Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils

6TI7 の概要

• エントリーDOI: 10.2210/pdb6ti7/pdb
• 関連するPDBエントリー: 6TI6
• NMR情報: BMRB: 34456
• 分子名称: Amyloid-beta precursor protein (2 entities in total)
• 機能のキーワード: amyloid beta peptides alzheimer's disease solid-state nmr supramolecular assembly, protein fibril
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 70847.51

構造登録者

Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, A.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C. (登録日: 2019-11-21, 公開日: 2020-07-22, 最終更新日: 2024-06-19)

主引用文献

Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, I.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C.
Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56:8830-8833, 2020

PubMed Abstract: Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio.

PubMed: 32749391
DOI: 10.1039/d0cc02463e

実験手法

SOLID-STATE NMR