6TH2

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP

Summary for 6TH2

• Entry DOI: 10.2210/pdb6th2/pdb
• Descriptor: Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: coabc, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoylcysteine decarboxylase, phosphopantothenoylcysteine synthetase, ligase
• Biological source: Mycolicibacterium smegmatis MC2 155
• Total number of polymer chains: 4
• Total formula weight: 102265.06

Authors

Mendes, V.,Blaszczyk, M.,Bryant, O.,Cory-Wright, J.,Blundell, T.L. (deposition date: 2019-11-18, release date: 2020-11-25, Last modification date: 2024-01-24)

• Primary citation: Mendes, V.,Green, S.R.,Evans, J.C.,Hess, J.,Blaszczyk, M.,Spry, C.,Bryant, O.,Cory-Wright, J.,Chan, D.S.,Torres, P.H.M.,Wang, Z.,Nahiyaan, N.,O'Neill, S.,Damerow, S.,Post, J.,Bayliss, T.,Lynch, S.L.,Coyne, A.G.,Ray, P.C.,Abell, C.,Rhee, K.Y.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Wyatt, P.G.,Blundell, T.L.; Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.; Nat Commun, 12:143-143, 2021; PubMed: 33420031; DOI: 10.1038/s41467-020-20224-x

Experimental method

X-RAY DIFFRACTION (1.844 Å)