6TGW

Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor

Summary for 6TGW

• Entry DOI: 10.2210/pdb6tgw/pdb
• Related: 5FHZ
• Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate, ... (4 entities in total)
• Functional Keywords: aldh1a3, aldehyde dehydrogenase aldh inhibitor cancer stem cell, glioblastoma mesenchymal stem cell stem cell, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 228856.30

Authors

Garavaglia, S.,Rizzi, M. (deposition date: 2019-11-18, release date: 2021-06-02, Last modification date: 2024-01-24)

• Primary citation: Li, J.,Garavaglia, S.,Ye, Z.,Moretti, A.,Belyaeva, O.V.,Beiser, A.,Ibrahim, M.,Wilk, A.,McClellan, S.,Klyuyeva, A.V.,Goggans, K.R.,Kedishvili, N.Y.,Salter, E.A.,Wierzbicki, A.,Migaud, M.E.,Mullett, S.J.,Yates, N.A.,Camacho, C.J.,Rizzi, M.,Sobol, R.W.; A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.; Commun Biol, 4:1420-1420, 2021; PubMed: 34934174; DOI: 10.1038/s42003-021-02949-7

Experimental method

X-RAY DIFFRACTION (2.8 Å)