6TEW

Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the 2-aminothiazole-type inhibitor 27

Summary for 6TEW

Entry DOI	10.2210/pdb6tew/pdb
Related	6TE2
Descriptor	Casein kinase II subunit alpha', 4-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)amino]-2-oxidanyl-benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protein kinase ck2, casein kinase 2, atp-competitive inhibitor, 2-aminothiazole derivative, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43366.40
Authors	Niefind, K.,Lindenblatt, D.,Jose, J.,Applegate, V.M.,Nickelsen, A. (deposition date: 2019-11-12, release date: 2020-07-08, Last modification date: 2024-05-15)
Primary citation	Lindenblatt, D.,Nickelsen, A.,Applegate, V.M.,Jose, J.,Niefind, K. Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2. J.Med.Chem., 63:7766-7772, 2020 Cited by PubMed: 32589844 DOI: 10.1021/acs.jmedchem.0c00587 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.082 Å)

Structure validation