6TED

Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1

Summary for 6TED

• Entry DOI: 10.2210/pdb6ted/pdb
• EMDB information: 10480
• Descriptor: DNA-directed RNA polymerase subunit, Uncharacterized protein, Transcription elongation factor SPT6, ... (26 entities in total)
• Functional Keywords: polymerase, elongation complex, rna, dna, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 24
• Total formula weight: 1351868.46

Authors

Vos, S.M.,Farnung, L.,Cramer, P. (deposition date: 2019-11-11, release date: 2020-07-22)

• Primary citation: Vos, S.M.,Farnung, L.,Linden, A.,Urlaub, H.,Cramer, P.; Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.; Nat.Struct.Mol.Biol., 27:668-677, 2020; PubMed: 32541898; DOI: 10.1038/s41594-020-0437-1

Experimental method

ELECTRON MICROSCOPY (3.1 Å)