6TE7

The structure of CYP121 in complex with inhibitor S2

6TE7 の概要

• エントリーDOI: 10.2210/pdb6te7/pdb
• 分子名称: Mycocyclosin synthase, 2-chloranyl-4-[4-[(1~{R})-1-imidazol-1-ylprop-2-enyl]phenyl]phenol, TRIETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: cyp121, complex, inhibitor, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44445.37

構造登録者

Adam, S.,Koehnke, J. (登録日: 2019-11-11, 公開日: 2021-05-26, 最終更新日: 2024-01-24)

• 主引用文献: Walter, I.,Adam, S.,Gentilini, M.V.,Kany, A.M.,Brengel, C.,Thomann, A.,Sparwasser, T.,Kohnke, J.,Hartmann, R.W.; Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.; Chemmedchem, 16:2786-2801, 2021; PubMed: 34010508; DOI: 10.1002/cmdc.202100283

実験手法

X-RAY DIFFRACTION (1.50001818022 Å)