6TDT

Thrombin in Complex with a D-DiPhe-Pro-p-pyridine derivative

6TDT の概要

• エントリーDOI: 10.2210/pdb6tdt/pdb
• 分子名称: Prothrombin, Hirudin variant-2, PHOSPHATE ION, ... (9 entities in total)
• 機能のキーワード: coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, preorganization, glycosylation, blood, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36237.10

構造登録者

Ngo, K.,Heine, A.,Klebe, G. (登録日: 2019-11-10, 公開日: 2020-05-13, 最終更新日: 2024-01-24)

• 主引用文献: Ngo, K.,Collins-Kautz, C.,Gerstenecker, S.,Wagner, B.,Heine, A.,Klebe, G.; Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?; J.Med.Chem., 63:3274-3289, 2020; PubMed: 32011145; DOI: 10.1021/acs.jmedchem.9b02061

実験手法

X-RAY DIFFRACTION (1.53 Å)