6TD5
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Summary for 6TD5
Entry DOI | 10.2210/pdb6td5/pdb |
EMDB information | 10463 |
Descriptor | Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit family protein, ... (16 entities in total) |
Functional Keywords | proteasome complex, inhibitor, peptidase, hydrolase |
Biological source | Leishmania donovani More |
Total number of polymer chains | 28 |
Total formula weight | 810599.43 |
Authors | Srinivas, H. (deposition date: 2019-11-07, release date: 2020-08-26, Last modification date: 2020-10-21) |
Primary citation | Nagle, A.,Biggart, A.,Be, C.,Srinivas, H.,Hein, A.,Caridha, D.,Sciotti, R.J.,Pybus, B.,Kreishman-Deitrick, M.,Bursulaya, B.,Lai, Y.H.,Gao, M.Y.,Liang, F.,Mathison, C.J.N.,Liu, X.,Yeh, V.,Smith, J.,Lerario, I.,Xie, Y.,Chianelli, D.,Gibney, M.,Berman, A.,Chen, Y.L.,Jiricek, J.,Davis, L.C.,Liu, X.,Ballard, J.,Khare, S.,Eggimann, F.K.,Luneau, A.,Groessl, T.,Shapiro, M.,Richmond, W.,Johnson, K.,Rudewicz, P.J.,Rao, S.P.S.,Thompson, C.,Tuntland, T.,Spraggon, G.,Glynne, R.J.,Supek, F.,Wiesmann, C.,Molteni, V. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63:10773-10781, 2020 Cited by PubMed: 32667203DOI: 10.1021/acs.jmedchem.0c00499 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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