6TD5

Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib

6TD5 の概要

• エントリーDOI: 10.2210/pdb6td5/pdb
• EMDBエントリー: 10463
• 分子名称: Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit family protein, ... (16 entities in total)
• 機能のキーワード: proteasome complex, inhibitor, peptidase, hydrolase
• 由来する生物種: Leishmania donovani; 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 810599.43

構造登録者

Srinivas, H. (登録日: 2019-11-07, 公開日: 2020-08-26, 最終更新日: 2020-10-21)

• 主引用文献: Nagle, A.,Biggart, A.,Be, C.,Srinivas, H.,Hein, A.,Caridha, D.,Sciotti, R.J.,Pybus, B.,Kreishman-Deitrick, M.,Bursulaya, B.,Lai, Y.H.,Gao, M.Y.,Liang, F.,Mathison, C.J.N.,Liu, X.,Yeh, V.,Smith, J.,Lerario, I.,Xie, Y.,Chianelli, D.,Gibney, M.,Berman, A.,Chen, Y.L.,Jiricek, J.,Davis, L.C.,Liu, X.,Ballard, J.,Khare, S.,Eggimann, F.K.,Luneau, A.,Groessl, T.,Shapiro, M.,Richmond, W.,Johnson, K.,Rudewicz, P.J.,Rao, S.P.S.,Thompson, C.,Tuntland, T.,Spraggon, G.,Glynne, R.J.,Supek, F.,Wiesmann, C.,Molteni, V.; Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.; J.Med.Chem., 63:10773-10781, 2020; PubMed: 32667203; DOI: 10.1021/acs.jmedchem.0c00499

実験手法

ELECTRON MICROSCOPY (3.2 Å)