6TD1

Crystal structure of VNRX-5133 (taniborbactam) bound to KPC-2

6TD1 の概要

• エントリーDOI: 10.2210/pdb6td1/pdb
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: inhibitor, boronate, beta-lactamase, antimicrobial protein
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31480.11

構造登録者

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (登録日: 2019-11-07, 公開日: 2020-01-22, 最終更新日: 2024-01-24)

• 主引用文献: Tooke, C.L.,Hinchliffe, P.,Krajnc, A.,Mulholland, A.J.,Brem, J.,Schofield, C.J.,Spencer, J.; Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition.; Rsc Med Chem, 11:491-496, 2020; PubMed: 33479650; DOI: 10.1039/c9md00557a

実験手法

X-RAY DIFFRACTION (1.2 Å)