6TCX
Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis
This is a non-PDB format compatible entry.
Summary for 6TCX
Entry DOI | 10.2210/pdb6tcx/pdb |
Descriptor | Papain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2~{R})-2-[[(1~{S})-1-[(6~{S})-2-azanyl-1,4,5,6-tetrahydropyrimidin-6-yl]-2-[[(2~{S})-3-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]amino]-2-oxidanylidene-ethyl]carbamoylamino]-3-(4-hydroxyphenyl)propanoic acid, ... (4 entities in total) |
Functional Keywords | peptide inhibitor, cysteine protease, papain, structural genomics consortium, sgc, hydrolase |
Biological source | Carica papaya (Papaya) |
Total number of polymer chains | 1 |
Total formula weight | 24302.29 |
Authors | Kraemer, A.,Juettner, N.E.,Fuchsbauer, H.-L.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-11-06, release date: 2019-12-04, Last modification date: 2024-01-24) |
Primary citation | Juettner, N.E.,Bogen, J.P.,Bauer, T.A.,Knapp, S.,Pfeifer, F.,Huettenhain, S.H.,Meusinger, R.,Kraemer, A.,Fuchsbauer, H.L. Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway. J.Nat.Prod., 83:2983-2995, 2020 Cited by PubMed: 32998509DOI: 10.1021/acs.jnatprod.0c00201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report