6TCX

Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis

これはPDB形式変換不可エントリーです。

6TCX の概要

• エントリーDOI: 10.2210/pdb6tcx/pdb
• 分子名称: Papain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2~{R})-2-[[(1~{S})-1-[(6~{S})-2-azanyl-1,4,5,6-tetrahydropyrimidin-6-yl]-2-[[(2~{S})-3-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]amino]-2-oxidanylidene-ethyl]carbamoylamino]-3-(4-hydroxyphenyl)propanoic acid, ... (4 entities in total)
• 機能のキーワード: peptide inhibitor, cysteine protease, papain, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Carica papaya (Papaya)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24302.29

構造登録者

Kraemer, A.,Juettner, N.E.,Fuchsbauer, H.-L.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2019-11-06, 公開日: 2019-12-04, 最終更新日: 2024-10-09)

• 主引用文献: Juettner, N.E.,Bogen, J.P.,Bauer, T.A.,Knapp, S.,Pfeifer, F.,Huettenhain, S.H.,Meusinger, R.,Kraemer, A.,Fuchsbauer, H.L.; Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.; J.Nat.Prod., 83:2983-2995, 2020; PubMed: 32998509; DOI: 10.1021/acs.jnatprod.0c00201

実験手法

X-RAY DIFFRACTION (1.65 Å)