6TCU

Glycogen synthase kinase-3 beta (GSK3b) in complex with ligand 1

Summary for 6TCU

• Entry DOI: 10.2210/pdb6tcu/pdb
• Descriptor: Glycogen synthase kinase-3 beta, 5-[2,3-bis(fluoranyl)phenyl]-~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1~{H}-indazole-3-carboxamide, ACETATE ION, ... (4 entities in total)
• Functional Keywords: gsk3beta kinase, transferase, inhibitor, proteros
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 40887.87

Authors

Lammens, A.,Krapp, S.,Buonfiglio, R.,Ombrato, R. (deposition date: 2019-11-06, release date: 2020-09-16)

• Primary citation: Prati, F.,Buonfiglio, R.,Furlotti, G.,Cavarischia, C.,Mangano, G.,Picollo, R.,Oggianu, L.,di Matteo, A.,Olivieri, S.,Bovi, G.,Porceddu, P.F.,Reggiani, A.,Garrone, B.,Di Giorgio, F.P.,Ombrato, R.; Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue andIn VivoActivity in a Mood Disorder Model.; Acs Med.Chem.Lett., 11:825-831, 2020; PubMed: 32435391; DOI: 10.1021/acsmedchemlett.9b00633

Experimental method

X-RAY DIFFRACTION (2.14 Å)