6TCU
Glycogen synthase kinase-3 beta (GSK3b) in complex with ligand 1
Summary for 6TCU
Entry DOI | 10.2210/pdb6tcu/pdb |
Descriptor | Glycogen synthase kinase-3 beta, 5-[2,3-bis(fluoranyl)phenyl]-~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1~{H}-indazole-3-carboxamide, ACETATE ION, ... (4 entities in total) |
Functional Keywords | gsk3beta kinase, transferase, inhibitor, proteros |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40887.87 |
Authors | Lammens, A.,Krapp, S.,Buonfiglio, R.,Ombrato, R. (deposition date: 2019-11-06, release date: 2020-09-16) |
Primary citation | Prati, F.,Buonfiglio, R.,Furlotti, G.,Cavarischia, C.,Mangano, G.,Picollo, R.,Oggianu, L.,di Matteo, A.,Olivieri, S.,Bovi, G.,Porceddu, P.F.,Reggiani, A.,Garrone, B.,Di Giorgio, F.P.,Ombrato, R. Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue andIn VivoActivity in a Mood Disorder Model. Acs Med.Chem.Lett., 11:825-831, 2020 Cited by PubMed: 32435391DOI: 10.1021/acsmedchemlett.9b00633 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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