6TCG

2'-F-riboguanosine and 2'-F-arabinoguanosine modified G-quadruplex with V-loop and all-syn G-tract

6TCG の概要

• エントリーDOI: 10.2210/pdb6tcg/pdb
• 関連するPDBエントリー: 6TC8
• NMR情報: BMRB: 34445
• 分子名称: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GF2)P*(GFL)P*GP*GP*AP*CP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: g-quadruplex, v-loop, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7008.47

構造登録者

Haase, L.,Weisz, K. (登録日: 2019-11-06, 公開日: 2020-03-25, 最終更新日: 2024-05-15)

主引用文献

Haase, L.,Weisz, K.
Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions.
Chem.Commun.(Camb.), 56:4539-4542, 2020

PubMed Abstract: Mixed 2'-F-riboguanosine and 2'-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.

PubMed: 32202271
DOI: 10.1039/d0cc01285h

実験手法

SOLUTION NMR