6TAP

Structure of the dArc1 capsid

6TAP の概要

• エントリーDOI: 10.2210/pdb6tap/pdb
• EMDBエントリー: 10423
• 分子名称: Activity-regulated cytoskeleton associated protein 1, ZINC ION (2 entities in total)
• 機能のキーワード: darc, gag, virus, vlp, virus like particle
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 144671.41

構造登録者

Erlendsson, S.,Morado, D.R.,Shepherd, J.D.,Briggs, J.A.G. (登録日: 2019-10-30, 公開日: 2020-01-01, 最終更新日: 2024-07-10)

主引用文献

Erlendsson, S.,Morado, D.R.,Cullen, H.B.,Feschotte, C.,Shepherd, J.D.,Briggs, J.A.G.
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Nat.Neurosci., 23:172-175, 2020

PubMed Abstract: Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

PubMed: 31907439
DOI: 10.1038/s41593-019-0569-y

実験手法

ELECTRON MICROSCOPY (3.5 Å)