6T9U

Bovine Trypsine in complex with the synthetic inhibitor (S)-3'-(N-(1-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboximidamide (MI-490)

6T9U の概要

• エントリーDOI: 10.2210/pdb6t9u/pdb
• 分子名称: Cationic Trypsin, DIMETHYL SULFOXIDE, 1-~{tert}-butyl-3-[1-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-(3-carbamimidoylphenyl)phenyl]sulfonylamino]propanoyl]piperidin-4-yl]urea, ... (6 entities in total)
• 機能のキーワード: trypsin, hydrolase
• 由来する生物種: Bos taurus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26763.37

構造登録者

Mueller, J.M.,Merkl, S.,Keils, A.,Pilgram, O.,Steinmetzer, T. (登録日: 2019-10-28, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Pilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T.; Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors; Eur.J.Med.Chem., :114437-, 2022; DOI: 10.1016/j.ejmech.2022.114437

実験手法

X-RAY DIFFRACTION (1.0675090501 Å)