6T9C

Crystal structure of the complex between PPARgamma LBD and the ligand NV1346 (3a)

Summary for 6T9C

Entry DOI	10.2210/pdb6t9c/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 4-hexoxy-~{N}-[(2~{S})-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]benzamide (3 entities in total)
Functional Keywords	transcription factor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69502.24
Authors	Pochetti, G.,Montanari, R.,Capelli, D. (deposition date: 2019-10-27, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	Montanari, R.,Capelli, D.,Yamamoto, K.,Awaishima, H.,Nishikata, K.,Barendregt, A.,Heck, A.J.R.,Loiodice, F.,Altieri, F.,Paiardini, A.,Grottesi, A.,Pirone, L.,Pedone, E.,Peiretti, F.,Brunel, J.M.,Itoh, T.,Pochetti, G. Insights into PPAR gamma Phosphorylation and Its Inhibition Mechanism. J.Med.Chem., 63:4811-4823, 2020 Cited by PubMed: 32239932 DOI: 10.1021/acs.jmedchem.0c00048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation