6T97

Trypanothione Reductase from Leismania infantum in complex with TRL190

Summary for 6T97

• Entry DOI: 10.2210/pdb6t97/pdb
• Related: 6T95
• Descriptor: Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, oxidoreductase, leishmania, drug, flavoprotein
• Biological source: Leishmania infantum
• Total number of polymer chains: 1
• Total formula weight: 54945.80

Authors

Carriles, A.,Hermoso, J.A. (deposition date: 2019-10-26, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Revuelto, A.,de Lucio, H.,Carriles, A.,Garcia Soriano, J.C.,Sanchez-Murcia, P.A.,Hermoso, J.A.,Gago, F.,Camarasa, M.J.,Jimenez-Ruiz, A.,Velazquez, S.; Scaffold hopping identifies new triazole-and triazolium-based inhibitors of Leishmania infantum Trypanothione Reductase with potent and selective antileishmanial activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)