6T8X

Crystal structure of MAPKAPK2 (MK2) complexed with PF-3644022 and 5-(4-bromophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide

Summary for 6T8X

• Entry DOI: 10.2210/pdb6t8x/pdb
• Descriptor: MAP kinase-activated protein kinase 2, (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: kinase, non-atp competitive inhibitor, type4, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 226437.52

Authors

Beaumont, E.J.,Barker, J. (deposition date: 2019-10-25, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Beaumont, E.J.,Barker, J.; Crystal structure of MAPKAPK2 (MK2) complexed with PF-3644022 and 5-(4-bromophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.81 Å)