6T7H

Crystal structure of Thrombin in complex with macrocycle N14-PR4-A

6T7H の概要

• エントリーDOI: 10.2210/pdb6t7h/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: serine protease, blood clotting factor, inhibition, macrocycle, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69673.58

構造登録者

Angelini, A.,Kumar, M.G.,Heinis, C.,Cendron, L. (登録日: 2019-10-22, 公開日: 2020-09-30, 最終更新日: 2024-01-24)

• 主引用文献: Mothukuri, G.K.,Kale, S.S.,Stenbratt, C.L.,Zorzi, A.,Vesin, J.,Bortoli Chapalay, J.,Deyle, K.,Turcatti, G.,Cendron, L.,Angelini, A.,Heinis, C.; Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries.; Chem Sci, 11:7858-7863, 2020; PubMed: 34094158; DOI: 10.1039/d0sc01944e

実験手法

X-RAY DIFFRACTION (2.32 Å)