6T6N

Crystal structure of Klebsiella pneumoniae FabG2(NADH-dependent) in complex with NADH at 2.5 A resolution

6T6N の概要

• エントリーDOI: 10.2210/pdb6t6n/pdb
• 分子名称: 3-oxoacyl-[acyl-carrier protein] reductase, GLYCEROL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: fatty acid biosynthesis, fabg, (3-oxoacyl-(acyl-carrier-protein) reductase), nadh, nadph, complex, fas-ii, biosynthetic protein
• 由来する生物種: Klebsiella pneumoniae 30684/NJST258_2
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 212354.04

構造登録者

Vella, P.,Schnell, R.,Lindqvist, Y.,Schneider, G. (登録日: 2019-10-18, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Vella, P.,Rudraraju, R.S.,Lundback, T.,Axelsson, H.,Almqvist, H.,Vallin, M.,Schneider, G.,Schnell, R.; A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.; Bioorg.Med.Chem., 30:115898-115898, 2021; PubMed: 33388594; DOI: 10.1016/j.bmc.2020.115898

実験手法

X-RAY DIFFRACTION (2.5 Å)