6T5W

Cationic Trypsin in Complex with a D-Phe-Pro-p-aminopyridine Derivative (cocrystallizaton at 291 K)

Summary for 6T5W

• Entry DOI: 10.2210/pdb6t5w/pdb
• Descriptor: Cationic Trypsin, CALCIUM ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: hydrolase, protease, serine protease, digestion, metal ion binding
• Biological source: Bos taurus (Cattle)
• Total number of polymer chains: 1
• Total formula weight: 26387.92

Authors

Ngo, K.,Heine, A.,Klebe, G. (deposition date: 2019-10-17, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Ngo, K.,Collins-Kautz, C.,Gerstenecker, S.,Wagner, B.,Heine, A.,Klebe, G.; Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?; J.Med.Chem., 63:3274-3289, 2020; PubMed: 32011145; DOI: 10.1021/acs.jmedchem.9b02061

Experimental method

X-RAY DIFFRACTION (1.13 Å)