6T5W
Cationic Trypsin in Complex with a D-Phe-Pro-p-aminopyridine Derivative (cocrystallizaton at 291 K)
Summary for 6T5W
Entry DOI | 10.2210/pdb6t5w/pdb |
Descriptor | Cationic Trypsin, CALCIUM ION, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | hydrolase, protease, serine protease, digestion, metal ion binding |
Biological source | Bos taurus (Cattle) |
Total number of polymer chains | 1 |
Total formula weight | 26387.92 |
Authors | |
Primary citation | Ngo, K.,Collins-Kautz, C.,Gerstenecker, S.,Wagner, B.,Heine, A.,Klebe, G. Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J.Med.Chem., 63:3274-3289, 2020 Cited by PubMed: 32011145DOI: 10.1021/acs.jmedchem.9b02061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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