6T5V

KRasG12C ligand complex

Summary for 6T5V

Entry DOI	10.2210/pdb6t5v/pdb
Descriptor	GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	gtpase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20198.16
Authors	Phillips, C. (deposition date: 2019-10-17, release date: 2020-02-19, Last modification date: 2024-05-01)
Primary citation	Kettle, J.G.,Bagal, S.K.,Bickerton, S.,Bodnarchuk, M.S.,Breed, J.,Carbajo, R.J.,Cassar, D.J.,Chakraborty, A.,Cosulich, S.,Cumming, I.,Davies, M.,Eatherton, A.,Evans, L.,Feron, L.,Fillery, S.,Gleave, E.S.,Goldberg, F.W.,Harlfinger, S.,Hanson, L.,Howard, M.,Howells, R.,Jackson, A.,Kemmitt, P.,Kingston, J.K.,Lamont, S.,Lewis, H.J.,Li, S.,Liu, L.,Ogg, D.,Phillips, C.,Polanski, R.,Robb, G.,Robinson, D.,Ross, S.,Smith, J.M.,Tonge, M.,Whiteley, R.,Yang, J.,Zhang, L.,Zhao, X. Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C. J.Med.Chem., 63:4468-4483, 2020 Cited by PubMed: 32023060 DOI: 10.1021/acs.jmedchem.9b01720 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation