6T2E

Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions

6T2E の概要

• エントリーDOI: 10.2210/pdb6t2e/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, Stapled peptide GAR300-Gm (3 entities in total)
• 機能のキーワード: inhibitor, complex, mdm2, stapled peptides, ugi mcr-based macrocyclizations, peptide binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 11848.83

構造登録者

Groves, R.M.,Ali, M.A.,Atmaj, J.,van Oosterwijk, N.,Domling, A.,Rivera, G.D.,Ricardo, G.M. (登録日: 2019-10-08, 公開日: 2020-01-29, 最終更新日: 2024-01-24)

• 主引用文献: Ricardo, M.G.,Ali, A.M.,Plewka, J.,Surmiak, E.,Labuzek, B.,Neochoritis, C.G.,Atmaj, J.,Skalniak, L.,Zhang, R.,Holak, T.A.,Groves, M.,Rivera, D.G.,Domling, A.; Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.; Angew.Chem.Int.Ed.Engl., 59:5235-5241, 2020; PubMed: 31944488; DOI: 10.1002/anie.201916257

実験手法

X-RAY DIFFRACTION (2.4 Å)