6SWP
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH iBET-BD2 (GSK046)
This is a non-PDB format compatible entry.
Summary for 6SWP
Entry DOI | 10.2210/pdb6swp/pdb |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 4-acetamido-3-fluoranyl-~{N}-(4-oxidanylcyclohexyl)-5-[(1~{S})-1-phenylethoxy]benzamide, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13971.07 |
Authors | Chung, C. (deposition date: 2019-09-22, release date: 2020-04-01, Last modification date: 2024-05-15) |
Primary citation | Gilan, O.,Rioja, I.,Knezevic, K.,Bell, M.J.,Yeung, M.M.,Harker, N.R.,Lam, E.Y.N.,Chung, C.W.,Bamborough, P.,Petretich, M.,Urh, M.,Atkinson, S.J.,Bassil, A.K.,Roberts, E.J.,Vassiliadis, D.,Burr, M.L.,Preston, A.G.S.,Wellaway, C.,Werner, T.,Gray, J.R.,Michon, A.M.,Gobbetti, T.,Kumar, V.,Soden, P.E.,Haynes, A.,Vappiani, J.,Tough, D.F.,Taylor, S.,Dawson, S.J.,Bantscheff, M.,Lindon, M.,Drewes, G.,Demont, E.H.,Daniels, D.L.,Grandi, P.,Prinjha, R.K.,Dawson, M.A. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science, 368:387-394, 2020 Cited by PubMed: 32193360DOI: 10.1126/science.aaz8455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.604 Å) |
Structure validation
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