6SWG

Crystal structure of the TASOR-Periphilin core complex

6SWG の概要

• エントリーDOI: 10.2210/pdb6swg/pdb
• 分子名称: Periphilin-1, Protein TASOR, SULFATE ION (3 entities in total)
• 機能のキーワード: nuclear protein; transcriptional repressor; epigenetic silencing; histone h3 lysine 9 methylation (h3k9me3); transposable element; line1 element; low-complexity sequence; liquid-liquid phase separation (llps); membrane-less compartment; rna-binding protein, gene regulation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 31657.79

構造登録者

Prigozhin, D.M.,Freund, S.M.V.,Modis, Y. (登録日: 2019-09-20, 公開日: 2020-08-05, 最終更新日: 2020-10-21)

• 主引用文献: Prigozhin, D.M.,Douse, C.H.,Farleigh, L.E.,Albecka, A.,Tchasovnikarova, I.A.,Timms, R.T.,Oda, S.I.,Adolf, F.,Freund, S.M.V.,Maslen, S.,Lehner, P.J.,Modis, Y.; Periphilin self-association underpins epigenetic silencing by the HUSH complex.; Nucleic Acids Res., 48:10313-10328, 2020; PubMed: 32976585; DOI: 10.1093/nar/gkaa785

実験手法

X-RAY DIFFRACTION (2.51 Å)