6SUO

ERa_L536S (L536S/C381S/C471S,C530S) in complex with a tricyclic indole (compound 6)

Summary for 6SUO

Entry DOI	10.2210/pdb6suo/pdb
Descriptor	Estrogen receptor, (~{E})-3-[3,5-bis(fluoranyl)-4-[(1~{R},3~{R})-2-(2-fluoranyl-2-methyl-propyl)-1,3-dimethyl-4,9-dihydro-3~{H}-pyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid (3 entities in total)
Functional Keywords	oestrogen receptor, oestrogen binding domain, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	58224.04
Authors	Breed, J. (deposition date: 2019-09-16, release date: 2019-10-30, Last modification date: 2024-05-15)
Primary citation	Scott, J.S.,Breed, J.,Carbajo, R.J.,Davey, P.R.,Greenwood, R.,Huynh, H.K.,Klinowska, T.,Morrow, C.J.,Moss, T.A.,Polanski, R.,Nissink, J.W.M.,Varnes, J.,Yang, B. Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry. Acs Med.Chem.Lett., 10:1492-1497, 2019 Cited by PubMed: 31620239 DOI: 10.1021/acsmedchemlett.9b00370 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation