6SUO

ERa_L536S (L536S/C381S/C471S,C530S) in complex with a tricyclic indole (compound 6)

6SUO の概要

• エントリーDOI: 10.2210/pdb6suo/pdb
• 分子名称: Estrogen receptor, (~{E})-3-[3,5-bis(fluoranyl)-4-[(1~{R},3~{R})-2-(2-fluoranyl-2-methyl-propyl)-1,3-dimethyl-4,9-dihydro-3~{H}-pyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid (3 entities in total)
• 機能のキーワード: oestrogen receptor, oestrogen binding domain, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58224.04

構造登録者

Breed, J. (登録日: 2019-09-16, 公開日: 2019-10-30, 最終更新日: 2024-05-15)

• 主引用文献: Scott, J.S.,Breed, J.,Carbajo, R.J.,Davey, P.R.,Greenwood, R.,Huynh, H.K.,Klinowska, T.,Morrow, C.J.,Moss, T.A.,Polanski, R.,Nissink, J.W.M.,Varnes, J.,Yang, B.; Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.; Acs Med.Chem.Lett., 10:1492-1497, 2019; PubMed: 31620239; DOI: 10.1021/acsmedchemlett.9b00370

実験手法

X-RAY DIFFRACTION (1.74 Å)