6SSZ

Structure of the Plasmodium falciparum falcipain 2 protease in complex with an (E)-chalcone inhibitor.

6SSZ の概要

• エントリーDOI: 10.2210/pdb6ssz/pdb
• 分子名称: Cysteine proteinase falcipain 2a, (~{E})-3-(1,3-benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one (2 entities in total)
• 機能のキーワード: inhibitor, complex, malaria, haemoglobin, proteolysis, hydrolase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54953.84

構造登録者

Machin, J.,Kantsadi, A.,Vakonakis, I. (登録日: 2019-09-09, 公開日: 2019-12-04, 最終更新日: 2024-01-24)

• 主引用文献: Machin, J.M.,Kantsadi, A.L.,Vakonakis, I.; The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site.; Malar.J., 18:388-388, 2019; PubMed: 31791339; DOI: 10.1186/s12936-019-3043-0

実験手法

X-RAY DIFFRACTION (3.45 Å)