6SRH
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117
Summary for 6SRH
Entry DOI | 10.2210/pdb6srh/pdb |
Descriptor | Activin receptor type-1, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | kinase, bmp, inhibitor, signalling, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72495.10 |
Authors | Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-09-05, release date: 2019-09-18, Last modification date: 2024-01-24) |
Primary citation | Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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