6SRH

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117

Summary for 6SRH

• Entry DOI: 10.2210/pdb6srh/pdb
• Descriptor: Activin receptor type-1, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: kinase, bmp, inhibitor, signalling, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72495.10

Authors

Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-09-05, release date: 2019-09-18, Last modification date: 2024-01-24)

• Primary citation: Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.; Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)