6SQU

Crystal structure of human SHIP2 catalytic domain in complex with 1,2,4 Dimer

Summary for 6SQU

Entry DOI	10.2210/pdb6squ/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 5,5'-(ethane-1,2-diylbis(oxy))bis(benzene-5,4,2,1,-tetrayl)hexakisphosphate (3 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	73277.84
Authors	Whitfield, H.,Brearley, C.A.,Hemmings, A.M. (deposition date: 2019-09-04, release date: 2021-01-13, Last modification date: 2024-01-24)
Primary citation	Whitfield, H.,Hemmings, A.M.,Mills, S.J.,Baker, K.,White, G.,Rushworth, S.,Riley, A.M.,Potter, B.V.L.,Brearley, C.A. Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention. J.Med.Chem., 64:3813-3826, 2021 Cited by PubMed: 33724834 DOI: 10.1021/acs.jmedchem.0c01944 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation