6SQU

Crystal structure of human SHIP2 catalytic domain in complex with 1,2,4 Dimer

6SQU の概要

• エントリーDOI: 10.2210/pdb6squ/pdb
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 5,5'-(ethane-1,2-diylbis(oxy))bis(benzene-5,4,2,1,-tetrayl)hexakisphosphate (3 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73277.84

構造登録者

Whitfield, H.,Brearley, C.A.,Hemmings, A.M. (登録日: 2019-09-04, 公開日: 2021-01-13, 最終更新日: 2024-01-24)

• 主引用文献: Whitfield, H.,Hemmings, A.M.,Mills, S.J.,Baker, K.,White, G.,Rushworth, S.,Riley, A.M.,Potter, B.V.L.,Brearley, C.A.; Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.; J.Med.Chem., 64:3813-3826, 2021; PubMed: 33724834; DOI: 10.1021/acs.jmedchem.0c01944

実験手法

X-RAY DIFFRACTION (2.27 Å)