6SQR
Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub
Summary for 6SQR
Entry DOI | 10.2210/pdb6sqr/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin-40S ribosomal protein S27a, ... (10 entities in total) |
Functional Keywords | mdm2, mdmx, p53, e3, e2, ubiquitin, ubiquitin ligase, phosphorylation, ligase |
Biological source | Felis catus (Cat) More |
Total number of polymer chains | 12 |
Total formula weight | 132405.16 |
Authors | Magnussen, H.M.,Ahmed, S.F.,Huang, D.T. (deposition date: 2019-09-04, release date: 2020-05-06, Last modification date: 2024-01-24) |
Primary citation | Magnussen, H.M.,Ahmed, S.F.,Sibbet, G.J.,Hristova, V.A.,Nomura, K.,Hock, A.K.,Archibald, L.J.,Jamieson, A.G.,Fushman, D.,Vousden, K.H.,Weissman, A.M.,Huang, D.T. Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nat Commun, 11:2094-2094, 2020 Cited by PubMed: 32350255DOI: 10.1038/s41467-020-15783-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
Download full validation report