6SPW

Structure of protein kinase CK2 catalytic subunit with the CK2beta-competitive bisubstrate inhibitor ARC3140

Summary for 6SPW

• Entry DOI: 10.2210/pdb6spw/pdb
• Related: 5NUY
• Descriptor: Casein kinase II subunit alpha, ARC3140, SODIUM ION, ... (5 entities in total)
• Functional Keywords: protein kinase ck2 casein kinase 2 bisubstrate inhibitor, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 50036.47

Authors

Niefind, K.,Schnitzler, A. (deposition date: 2019-09-03, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Pietsch, M.,Viht, K.,Schnitzler, A.,Ekambaram, R.,Steinkruger, M.,Enkvist, E.,Nienberg, C.,Nickelsen, A.,Lauwers, M.,Jose, J.,Uri, A.,Niefind, K.; Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.; Bioorg.Chem., 96:103608-103608, 2020; PubMed: 32058103; DOI: 10.1016/j.bioorg.2020.103608

Experimental method

X-RAY DIFFRACTION (1.599 Å)