6SPU

Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 3-aminobenzoic acid

6SPU の概要

• エントリーDOI: 10.2210/pdb6spu/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, DIMETHYL SULFOXIDE, 3-AMINOBENZOIC ACID, ... (4 entities in total)
• 機能のキーワード: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41563.43

構造登録者

Oebbeke, M.,Siefker, C.,Heine, A.,Klebe, G. (登録日: 2019-09-02, 公開日: 2020-09-30, 最終更新日: 2024-01-24)

• 主引用文献: Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G.; Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.; Angew.Chem.Int.Ed.Engl., 60:252-258, 2021; PubMed: 33021032; DOI: 10.1002/anie.202011295

実験手法

X-RAY DIFFRACTION (1.39 Å)