6SP6

Ultra-high Resolution Crystal Structure of the CTX-M-15 Extended-Spectrum beta-Lactamase in Complex with Taniborbactam (VNRX-5133)

Summary for 6SP6

Entry DOI	10.2210/pdb6sp6/pdb
Descriptor	Beta-lactamase, SULFATE ION, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, ... (6 entities in total)
Functional Keywords	beta-lactamase, hydrolase, antibiotic resistance, beta-lactam hydrolysis
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	29154.57
Authors	Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2019-08-31, release date: 2020-01-22, Last modification date: 2024-01-24)
Primary citation	Liu, B.,Trout, R.E.L.,Chu, G.H.,McGarry, D.,Jackson, R.W.,Hamrick, J.C.,Daigle, D.M.,Cusick, S.M.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S.,Docquier, J.D.,Weiss, W.J.,Pevear, D.C.,Xerri, L.,Burns, C.J. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63:2789-2801, 2020 Cited by PubMed: 31765155 DOI: 10.1021/acs.jmedchem.9b01518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation