6SM2

Mutant immunoglobulin light chain causing amyloidosis (Pat-1)

Summary for 6SM2

• Entry DOI: 10.2210/pdb6sm2/pdb
• Related: 6SM1
• Descriptor: Pat-1 (2 entities in total)
• Functional Keywords: al amyloidosis, antibody folding, protein stability, dynamics, protein fibril
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 23529.52

Authors

Kazman, P.,Vielberg, M.-T.,Cendales, M.D.P.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Koehler, R.,Schoenland, S.,Groll, M.,Buchner, J. (deposition date: 2019-08-21, release date: 2020-03-18)

• Primary citation: Kazman, P.,Vielberg, M.T.,Pulido Cendales, M.D.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Kohler, R.,Schonland, S.,Groll, M.,Buchner, J.; Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation.; Elife, 9:-, 2020; PubMed: 32151314; DOI: 10.7554/eLife.52300

Experimental method

X-RAY DIFFRACTION (2.5 Å)